Design and Performance Evaluation of Residual Generators for the FDI of an Aircraft

In this work, several procedures for the fault detection and isolation (FDI) on general aviation aircraft sensors are presented. In order to provide a comprehensive wide–spectrum treatment, both linear and nonlinear, model–based and data–driven methodologies are considered. The main contributions of the paper are related to the development of both FDI polynomial method (PM) and FDI scheme based on the nonLinear geometric approach (NLGA). As to the PM, the obtained results highlight a good trade–off between solution complexity and resulting performances. Moreover, the proposed PM is especially useful when robust solutions are required for minimising the effects of modelling errors and noise, while maximising fault sensitivity. As to the NLGA, the proposed work is the first development and robust application of the NLGA to an aircraft model in flight conditions characterised by tight–coupled longitudinal and lateral dynamics. In order to verify the robustness of the residual generators related to the previous FDI techniques, the simulation results adopt a typical aircraft reference trajectory embedding several steady–state flight conditions, such as straight flight phases and coordinated turns. Moreover, the simulations are performed in the presence of both measurement and modelling errors. Finally, extensive simulations are used for assessing the overall capabilities of the developed FDI schemes and a comparison with neural networks (NN) and unknown input Kalman filter (UIKF) diagnosis methods is performed

Development and use of a Restorative Justice Ideology Instrument: Assessing beliefs

Researchers have noted that restorative justice (RJ) practices in schools seem to improve targeted outcomes (e.g. decreased office visits, increased grades, etc.). It has been acknowledged that a ‘grassroots’ (beliefs level) buy-in from teachers is necessary for the creation of a school environment that is in line with the ideals of RJ. In the current study, an operational definition for restorative justice ideology (RJI) was developed and used as the basis for the creation of a RJI measurement instrument. This is intended to facilitate understandings of the influence that RJ training has on individuals at the beliefs level, and whether the degree to which an individual holds an RJI is associated with the degree to which RJ practices are carried out at the classroom and school level. An exploratory factor analysis was conducted, a three-factor model was selected, and the instrument was tested for reliability and validity. The RJI was then used to investigate whether other individual differences were related to the RJI of teachers. The outcome of this study was the development of a psychometrically sound RJI instrument. Perspective taking, empathic concern, pupil control ideology, personal distress, and self-efficacy were identified as important characteristics of RJI

Electro-osmotic flows inside triangular microchannels

This work presents a numerical investigation of both pure electro-osmotic and combined electro-osmotic/pressure-driven flows inside triangular microchannels. A finite element analysis has been adopted to solve the governing equations for the electric potential and the velocity field, accounting for a finite thickness of the electric double layer. The influence of non-dimensional parameters such as the aspect ratio of the cross-section, the electrokinetic diameter and the ratio of the pressure force to the electric force on the flow behavior has been investigated. Numerical results point out that the velocity field is significantly influenced by the aspect ratio of the cross section and the electrokinetic diameter. More specifically, the aspect ratio plays an important role in determining the maximum volumetric flow rate, while the electrokinetic diameter is crucial to establishing the range of pressures that may be sustained by the electro-osmotic flow. Numerical results are also compared with two correlations available in the literature which enable to assess the volumetric flow rate and the pressure head for microchannels featuring a rectangular, a trapezoidal or an elliptical cross-section

On Estimating Edit Distance: Alignment, Dimension Reduction, and Embeddings

Edit distance is a fundamental measure of distance between strings and has been widely studied in computer science. While the problem of estimating edit distance has been studied extensively, the equally important question of actually producing an alignment (i.e., the sequence of edits) has received far less attention. Somewhat surprisingly, we show that any algorithm to estimate edit distance can be used in a black-box fashion to produce an approximate alignment of strings, with modest loss in approximation factor and small loss in run time. Plugging in the result of Andoni, Krauthgamer, and Onak, we obtain an alignment that is a (log n)^{O(1/epsilon^2)} approximation in time O~(n^{1 + epsilon}). Closely related to the study of approximation algorithms is the study of metric embeddings for edit distance. We show that min-hash techniques can be useful in designing edit distance embeddings through three results: (1) An embedding from Ulam distance (edit distance over permutations) to Hamming space that matches the best known distortion of O(log n) and also implicitly encodes a sequence of edits between the strings; (2) In the case where the edit distance between the input strings is known to have an upper bound K, we show that embeddings of edit distance into Hamming space with distortion f(n) can be modified in a black-box fashion to give distortion O(f(poly(K))) for a class of periodic-free strings; (3) A randomized dimension-reduction map with contraction c and asymptotically optimal expected distortion O(c), improving on the previous O~(c^{1 + 2 / log log log n}) distortion result of Batu, Ergun, and Sahinalp

Gastroparesis: New insights into an old disease

Gastroparesis (Gp) is a chronic disease characterized by a delayed gastric emptying in the absence of mechanical obstruction. Although this condition has been reported in the literature since the mid-1900s, only recently has there been renewed clinical and scientific interest in this disease, which has a potentially great impact on the quality of life. The aim of this review is to explore the pathophysiological, diagnostic and therapeutical aspects of Gp according to the most recent evidence. A comprehensive online search for Gp was carried out using MEDLINE and EMBASE. Gp is the result of neuromuscular abnormalities of the gastric motor function. There is evidence that patients with idiopathic and diabetic Gp may display a reduction in nitrergic inhibitory neurons and in interstitial cells of Cajal and/or telocytes. As regards diagnostic approach, 99-Technetium scintigraphy is currently considered to be the gold standard for Gp. Its limits are a lack of standardization and a mild risk of radiation exposure. The C13 breath testing is a valid and safe alternative method. 13C acid octanoic and the 13C Spirulina platensis recently approved by the Food and Drug Administration are the most commonly used diagnostic kits. The wireless motility capsule is a promising technique, but its use is limited by costs and scarce availability in many countries. Finally, therapeutic strategies are related to the clinical severity of Gp. In mild and moderate Gp, dietary modification and prokinetic agents are generally sufficient. Metoclopramide is the only drug approved by the Food and Drug Administration for Gp. However, other older and new prokinetics and antiemetics can be considered. As a second-line therapy, tricyclic antidepressants and cannabinoids have been proposed. In severe cases the normal nutritional approach can be compromised and artificial nutrition may be needed. In drug-unresponsive Gp patients some alternative strategies (endoscopic, electric stimulation or surgery) are available

Trade-off between photovoltaic systems installation and agricultural practices on arable lands: An environmental and socio-economic impact analysis for Italy

The paper introduces and discusses an open-source spatial-based model (called r.green.solar) able to quantify the energy production from solar photovoltaic (PV) ground-mounted panels. Socio-economic and environmental impacts can be evaluated by the model. The model starts from the theoretical quantity of solar PV potential energy and estimates a reduction of total amount of energy based on legal, technical, recommended and economic constraints. Model outputs were used for a trade-off analysis between energy production and traditional crops for food/feed cultivation on not irrigated arable land. The model was tested at regional level for a Mediterranean context (Italy). The results confirm that the economic profitability of PV systems follows a north-south gradient, but the main impacts are related to local peculiarities – such as the disposal of not irrigated arable land and the presence of constraints, in particular the landscape maintenance, the morphological variables and the specialization index – and crop yields. © 2016 Elsevier Ltd. All rightsreserved

Cross-cultural adaptation, reliability and validity of the Italian version of the craniofacial pain and disability inventory in patients with chronic temporomandibular joint disorders

BACKGROUND: To develop an Italian version of the Craniofacial Pain Disability Inventory (CFPDI-I) and investigate its psychometric abilities in patients with temporomandibular disorders (TMD). METHODS: The CFPDI was translated following international standards. The psychometric analyses included reliability by internal consistency (Cronbach's alpha) and test/retest stability (intraclass correlation coefficient, ICC); construct validity was investigated by matching (a priori hypotheses) the CFPDI-I with the Italian Neck Disability Index (NDI-I), a pain intensity numerical rating scale (NRS), the Italian Pain Catastrophising Scale (PCS-I), the Italian Tampa Scale of Kinesiophobia (TSK-I), and the Italian Migraine Disability Assessment Score Questionnaire (MIDAS) (Pearson's correlation). Alpha was set at 0.05. RESULTS: Two hundred and twelve patients with chronic TMD completed the tool. The questionnaire was internally consistent (\u3b1 =\u20090.95) and its stability was good (ICCs\u2009=\u20090.91). As hypothesised, validity figures showed CFPDI-I strongly correlated with the NDI-I (r =\u20090.66, p <\u20090.05) and moderately correlated with the NRS (r =\u20090.48, p <\u20090.05), PCS (r =\u20090.37, p <\u20090.05), TSKI (r =\u20090.35, p <\u20090.05) and MIDAS (r =\u20090.47, p <\u20090.05). Similar estimates were shown by CFPDI-I subscales. CONCLUSIONS: The cross-culturally adapted version of the Craniofacial Pain and Disability Inventory (CFPDI-I) showed satisfactory psychometric properties that replicate those of the original version and, therefore, can be implemented in the clinical assessment of Italian people affected by TMD

Extracorporeal cardiopulmonary resuscitation for cardiac arrest : a systematic review

Aim To assess the use of extracorporeal cardiopulmonary resuscitation (ECPR), compared with manual or mechanical cardiopulmonary resuscitation (CPR), for out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA) in adults and children. Methods The PRISMA guidelines were followed. We searched Medline, Embase, and Evidence-Based Medicine Reviews for randomized clinical trials and observational studies published before May 22, 2018. The population included adult and pediatric patients with OHCA and IHCA of any origin. Two investigators reviewed studies for relevance, extracted data, and assessed risk of bias using the ROBINS-I tool. Outcomes included short-term and long-term survival and favorable neurological outcome. Results We included 25 observational studies, of which 15 studies were in adult OHCA, 7 studies were in adult IHCA, and 3 studies were in pediatric IHCA. There were no studies in pediatric OHCA. No randomized trials were included. Results from individual studies were largely inconsistent, although several studies in adult and pediatric IHCA were in favor of ECPR. The risk of bias for individual studies was overall assessed to be critical, with confounding being the primary source of bias. The overall quality of evidence was assessed to be very low. Heterogeneity across studies precluded any meaningful meta-analyses. Conclusions There is inconclusive evidence to either support or refute the use of ECPR for OHCA and IHCA in adults and children. The quality of evidence across studies is very low

Mammary Gland Development as a Sensitive End Point after Acute Prenatal Exposure to an Atrazine Metabolite Mixture in Female Long-Evans Rats

BACKGROUND: Atrazine (ATR), a widely used chlorotriazine herbicide, inhibits a number of endocrine-dependent processes, including gonadotrophin surges and mammary gland development in rats. Chlorotriazine herbicides are rapidly metabolized in plants and animals to form a group of metabolites that are detected both in the environment and in exposed animals. The extent to which these metabolites are responsible directly for the observed health effects is not understood. OBJECTIVES: Our goal was to determine if a mixture of ATR metabolites, in proportions found in the environment, might produce developmental effects in Long-Evans rats following exposure late in pregnancy. METHODS: We administered an ATR metabolite mixture (AMM) containing ATR, hydroxyatrazine, diaminochlorotriazine, deethylatrazine, and deisopropylatrazine orally to pregnant Long-Evans rats at 0.09, 0.87, or 8.73 mg/kg body weight (bw)/day, on gestation days 15–19, using 0 and 100 mg ATR/kg bw/day as negative and positive controls, respectively. RESULTS: We observed no significant effect of acute AMM exposure on body weight gain in dams during the dosing period, weight loss in pups on postnatal day (PND)4, or pubertal timing, as is seen with ATR alone. However, as with ATR, we detected delayed mammary gland development, evaluated by whole mount analysis, as early as PND4 in all treatment groups. CONCLUSIONS: Our data suggest that acute exposure to AMM at levels as low as 0.09 mg/kg bw during late pregnancy causes persistent alterations in mammary gland development of female offspring, and that these effects do not appear to be related to bw or associated with pubertal timing